Sabine Fischer geb. Schamberg
|since 2011||Postdoc in the group of Ernst H. K. Stelzer, Buchmann Institute of Molecular Life Science (BMLS), Goethe University, Frankfurt am Main, Germany|
|2009 – 2011|
Postdoc in the group of Alfonso Martinez Arias, Department of Genetics, University of Cambridge, UK
PhD, University of Nottingham, UK
|2006 – 2009||PhD student with Markus Owen and Nick Monk, School of Mathematical Sciences, University of Nottingham, UK|
|2000 – 2005||Mathematics, Julius-Maximilians-University, Würzburg, Germany|
Biological processes occur over a wide range of time and length scales and rely on the coordination of the different parts. In particular, tissue architecture and function depend on the properties of the individual cells and the three-dimensional cell neighbourhood. The quantitative analysis of cell neighbourhood features is the main interest of my research.
In my previous research, I have focused on the role of intercellular interactions during Drosophila morphogenesis and three-dimensional cellular aggregation. My results provide insight into the mechanisms that affect tissue coherence, a topic of medical relevance since disruptions of these mechanisms are associated with a large number of diseases. Currently, I am involved in different projects that address the role of spatial interactions in the response of cells to drugs as well as in mouse embryogenesis.
All my projects are based on close collaborations with experimentalists. Together we use an image-based systems biology approach. The joint work comprises planning of the experiments, bioimage informatics and mathematical modelling. As a mathematician, my contributions to the work flow are advice regarding the experiments and active involvement in the theoretical parts.
Schmitz A*, Fischer SC*, Mattheyer C, Pampaloni F, Stelzer EHK (2017), Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids. Sci Reports 7:43693 (* authors contributed equally)
Dini S, Binder BJ, Fischer SC, Mattheyer C, Schmitz A, Stelzer EHK, Bean NG, Green JEF (2016), Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions. J R Soc Interface 13, 20160649
Mathew B, Schmitz A, Muñoz-Descalzo S, Ansari N, Pampaloni F, Stelzer EHK, Fischer SC (2015), Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition. BMC Bioinformatics, 16:187
Garg S*, Fischer SC*, Schuman EM°, Stelzer EHK° (2015), Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions. J R Soc Interface 12, 20141055 (*,° authors contributed equally)
Mateus AM, Gorfinkiel N, Schamberg S, Martinez Arias A (2011), Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila. PLoS One 6, e18729